[卵巢癌的分化程度与临床病程]

[The degree of differentiation and the clinical course of ovarian cancer].

作者信息

Vinokurov V L, Iurkova L E, Zagol'skaia V N

出版信息

Vopr Onkol. 1985;31(3):55-63.

Abstract

Clinical course versus morphological data on the level of tumor cell differentiation was studied in 323 cases of cancer of the ovaries. Level of cell differentiation proved to be of prognostic value, since it appeared to influence prognosis and clinical course greatly. Metastasis developed in 58.2 +/- 4.5% of patients suffering well-differentiated ovarian cancer. In cases of moderately- and poorly-differentiated cancer, it was 76.1 +/- 5.1 and 90.8 +/- 2.5%, respectively. The high level of tumor cell differentiation was registered in 41.8 +/- 4.5% of patients with cancer at early stages (I and II), while the low--level--in 9.2 +/- 2.5% only. This was matched by the predominance of poorly--differentiated tumors over those with high level of cell differentiation (90.8 +/- 2.5 and 58.2 +/- 4.5%, respectively). The five-year survival rate in patients with poorly--differentiated tumors was 8.3 +/- 2.5%, i. e. 7.8 times lower than in cases of tumors with high level of cell differentiation.

摘要

对323例卵巢癌患者的临床病程与肿瘤细胞分化水平的形态学数据进行了研究。细胞分化水平被证明具有预后价值，因为它似乎对预后和临床病程有很大影响。高分化卵巢癌患者中58.2±4.5%发生转移。在中分化和低分化癌病例中，转移率分别为76.1±5.1%和90.8±2.5%。早期（I期和II期）癌症患者中41.8±4.5%肿瘤细胞分化程度高，而低分化的仅占9.2±2.5%。这与低分化肿瘤多于高细胞分化肿瘤的情况相符（分别为90.8±2.5%和58.2±4.5%）。低分化肿瘤患者的五年生存率为8.3±2.5%，即比高细胞分化肿瘤患者低7.8倍。