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[各种形式酒精中毒的临床病理形态学与死因学]

[Clinical pathomorphology and tanatogenesis of various forms of alcoholic intoxication].

作者信息

Pavlov A L, Savin A A, Bogomolov D V, Pavlova A Z, Larev Z V

机构信息

The Centre for Rehabilitation of the Children with Severe Forms of Juvenile - Cerebral Paralysis, Moscow Health Department, Moscow, Russia, 125000.

Department of Neurology, Faculty of General Medicine, A.I. Evdokimov Moscow State Medical Stomatological University, Ministry of Health of the Russia, Moscow, Russia, 125000.

出版信息

Sud Med Ekspert. 2018;61(3):11-14. doi: 10.17116/sudmed2018613-14.

DOI:10.17116/sudmed2018613-14
PMID:29863713
Abstract

The objective of the present study was to identify the clinical and pathomorphological changes in the internal organs for the elucidation of the cause of death associated with various forms of alcoholic intoxication (chronic alcoholic intoxication, poisoning with surrogate alcohols, etc.). The analysis of the clinical conditions resulting from alcohol abuse has demonstrated that the principal pathology underlying the fatal outcome is complemented by a variety of non-lethal somatic disorders aggravating the patients' condition and enhancing its severity. The clinicians are known to give more attention to the accompanying somatic complications than to the cause underlying the main pathology (alcoholism). Such attitude in the absence of the adequate treatment of the alcohol dependency is neither clinically efficient nor economically appropriate. Poisoning with surrogate alcohols is characterized by the pulmonary-cerebral variant of tanatogenesis in the combination with hypercoagulation and the erosive processes in the gastrointestinal tract whereas death from alcoholic intoxication is usually associated with heart tanatogenesis.

摘要

本研究的目的是确定内脏器官的临床和病理形态学变化,以阐明与各种形式酒精中毒(慢性酒精中毒、代用酒精中毒等)相关的死亡原因。对酒精滥用导致的临床状况分析表明,导致致命后果的主要病理状况还伴有各种非致命性躯体疾病,这些疾病会加重患者病情并使其严重程度增加。众所周知,临床医生更多关注伴随的躯体并发症,而非主要病理状况(酒精中毒)的根本原因。在未对酒精依赖进行充分治疗的情况下,这种态度在临床治疗上既无效果,在经济上也不合适。代用酒精中毒的特征是死亡发生过程呈现肺脑型,同时伴有高凝状态和胃肠道糜烂性病变,而酒精中毒死亡通常与心脏性死亡发生过程有关。

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