肿瘤干细胞中的去泛素化酶：在癌症治疗中的功能和靶向抑制作用。
Deubiquitinating enzymes in cancer stem cells: functions and targeted inhibition for cancer therapy.
机构信息
Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea.
Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea; College of Medicine, Hanyang University, Seoul, South Korea.
出版信息
Drug Discov Today. 2018 Dec;23(12):1974-1982. doi: 10.1016/j.drudis.2018.05.035. Epub 2018 Jun 1.
The ability of cancers to evade conventional treatments, such as chemotherapy and radiation therapy, has been attributed to a subpopulation of cancer stem cells (CSCs). CSCs are regulated by mechanisms similar to those that regulate normal stem cells (NSCs), including processes involving ubiquitination and deubiquitination enzymes (DUBs) that regulate the expression of various factors, such as Notch, Wnt, Sonic Hedgehog (Shh), and Hippo. In this review, we discuss the roles of various DUBs involved in the regulation of core stem cell transcription factors and CSC-related proteins that are implicated in the modulation of cellular processes and carcinogenesis. In addition, we discuss the various DUB inhibitors that have been designed to target processes relevant to cancer and CSC maintenance.
癌症逃避传统治疗方法（如化疗和放射治疗）的能力归因于一小部分癌症干细胞（CSC）。CSC 受调控机制与调控正常干细胞（NSC）的机制相似，包括涉及泛素化和去泛素化酶（DUBs）的过程，这些酶调节各种因子的表达，如 Notch、Wnt、Sonic Hedgehog (Shh) 和 Hippo。在这篇综述中，我们讨论了参与调节核心干细胞转录因子和与 CSC 相关蛋白的各种 DUB 的作用，这些蛋白参与调节细胞过程和癌变。此外，我们还讨论了为针对与癌症和 CSC 维持相关的过程而设计的各种 DUB 抑制剂。
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