调节内源性血清素能镇痛系统的治疗意义。
Therapeutic implications of modifying endogenous serotonergic analgesic systems.
作者信息
Frier J W
出版信息
Anesth Prog. 1985 Jan-Feb;32(1):19-22.
Abstract
Basic research strongly implicates the neurotransmitter serotonin as a modulator of endogenous analgesic systems. Recently, clinical strategies have been developed to activate endogenous serotonergic systems as a therapeutic approach to pain control. This paper reviews the biochemistry, anatomical distribution, and physiologic functions of serotonin. The evidence reviewed suggests that precursor loading to increase brain serotonin levels and administration of serotonin receptor inhibitors and serotonin receptor agonists may lead to novel methods of pain control and the development of useful analgesic drugs.
摘要
基础研究有力地表明神经递质5-羟色胺是内源性镇痛系统的一种调节因子。最近，已经开发出临床策略来激活内源性5-羟色胺能系统，作为控制疼痛的一种治疗方法。本文综述了5-羟色胺的生物化学、解剖分布及生理功能。所综述的证据表明，通过前体负荷来提高脑内5-羟色胺水平以及给予5-羟色胺受体抑制剂和5-羟色胺受体激动剂，可能会带来控制疼痛的新方法，并促进有用镇痛药物的研发。
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