增生性视网膜病变和黄斑病变是镰状细胞病中的两种独立病症：血液流变学是否起作用？1.

Proliferative retinopathy and maculopathy are two independent conditions in sickle cell disease: Is there a role of blood rheology?1.

机构信息

Service d'Ophtalmologie, CHU de Pointe-à-Pitre/Abymes, route de Chauvel, Pointe-à-Pitre, Guadeloupe, France.

Université des Antilles, CHU dePointe-à-Pitre, Guadeloupe, Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, INTS, Unité Biologie Intégrée du Globule Rouge UMR_S1134, Paris, France.

出版信息

Clin Hemorheol Microcirc. 2019;71(3):337-345. doi: 10.3233/CH-180412.

DOI:10.3233/CH-180412

PMID:29865045

Abstract

OBJECTIVE

Our study investigated the prevalence of retinopathy and maculopathy in sickle cell patients and tested the association between these two conditions. In addition, we tested whether hematological and hemorheological parameters, as well as genotype, were involved in the development of these two conditions.

METHODS

Seventy sickle cell adult patients were recruited: 37 with sickle cell anemia (SCA) and 33 with sickle cell hemoglobin C disease (SCC). All patients underwent retinal examination and macular ocular coherence tomography. Blood was sampled for the measurements of hematological and hemorheological parameters.

RESULTS

Twenty-six patients had maculopathy and 30 had retinopathy with no significant difference between SCA and SCC patients. No association between the presence of retinopathy and maculopathy was detected. RBC aggregation was higher and RBC deformability lower at 3 Pa in SCA patients. Blood viscosity and hematocrit were higher in SCC than in SCA patients. However, no association was found between biological parameters and the ocular complications studied.

CONCLUSIONS

Our study showed that retinopathy and maculopathy are common in sickle cell disease. Nevertheless, we found no association with hematological parameters, blood rheology or genotype.

摘要

目的

本研究调查了镰状细胞病患者中视网膜病变和黄斑病变的患病率，并检验了这两种疾病之间的相关性。此外，我们还检测了血液学和血液流变学参数以及基因型是否与这两种疾病的发生有关。

方法

招募了 70 名镰状细胞成年患者：37 名镰状细胞贫血（SCA）患者和 33 名镰状细胞血红蛋白 C 病（SCC）患者。所有患者均接受了视网膜检查和黄斑眼部相干断层扫描。采集血液样本以测量血液学和血液流变学参数。

结果

26 名患者患有黄斑病变，30 名患者患有视网膜病变，SCA 和 SCC 患者之间无明显差异。未发现视网膜病变和黄斑病变之间存在相关性。在 3 Pa 时，SCA 患者的 RBC 聚集率更高，RBC 变形能力更低。SCC 患者的血液黏度和血细胞比容高于 SCA 患者。然而，未发现生物学参数与研究的眼部并发症之间存在关联。