Adenosine-homocysteine interactions in controlling cyclic AMP in rat brain cortical slices.
作者信息
Newman M E
出版信息
Biochem Pharmacol. 1985 May 1;34(9):1435-8. doi: 10.1016/0006-2952(85)90681-1.
PMID:2986646
Abstract
Preincubation of rat brain cortical slices with homocysteine resulted in a reduction of the cyclic AMP response to subsequently added noradrenaline or isoproterenol. There was no effect of homocysteine on the adenosine response, nor of added S-adenosyl homocysteine on any of the responses studied. The results are interpreted in terms of binding of endogenous adenosine by the enzyme S-adenosylhomocysteinase, and provide further evidence for the controlling role of adenosine on cerebral cyclic AMP production.
摘要
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