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除心跳间期外，通过收缩强度评估的窦房结逐搏变异性。

Sinoatrial Beat to Beat Variability Assessed by Contraction Strength in Addition to the Interbeat Interval.

作者信息

Ahammer Helmut, Scheruebel Susanne, Arnold Robert, Mayrhofer-Reinhartshuber Michael, Lang Petra, Dolgos Ádám, Pelzmann Brigitte, Zorn-Pauly Klaus

机构信息

Institute of Biophysics, Medical University of Graz, Graz, Austria.

KML Vision OG, Graz, Austria.

出版信息

Front Physiol. 2018 May 18;9:546. doi: 10.3389/fphys.2018.00546. eCollection 2018.

DOI:10.3389/fphys.2018.00546
PMID:29867582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5968354/
Abstract

Beat to beat variability of cardiac tissue or isolated cells is frequently investigated by determining time intervals from electrode measurements in order to compute scale dependent or scale independent parameters. In this study, we utilize high-speed video camera recordings to investigate the variability of intervals as well as mechanical contraction strengths and relative contraction strengths with nonlinear analyses. Additionally, the video setup allowed us simultaneous electrode registrations of extracellular potentials. Sinoatrial node tissue under control and acetylcholine treated conditions was used to perform variability analyses by computing sample entropies and Higuchi dimensions. Beat to beat interval variabilities measured by the two recording techniques correlated very well, and therefore, validated the video analyses for this purpose. Acetylcholine treatment induced a reduction of beating rate and contraction strength, but the impact on interval variability was negligible. Nevertheless, the variability analyses of contraction strengths revealed significant differences in sample entropies and Higuchi dimensions between control and acetylcholine treated tissue. Therefore, the proposed high-speed video camera technique might represent a non-invasive tool that allows long-lasting recordings for detecting variations in beating behavior over a large range of scales.

摘要

心脏组织或分离细胞的逐搏变异性通常通过确定电极测量的时间间隔来研究，以便计算尺度依赖或尺度独立的参数。在本研究中，我们利用高速摄像机记录，通过非线性分析来研究间隔变异性以及机械收缩强度和相对收缩强度。此外，视频设置允许我们同时记录细胞外电位的电极信号。在对照和乙酰胆碱处理条件下的窦房结组织用于通过计算样本熵和 Higuchi 维数来进行变异性分析。通过两种记录技术测量的逐搏间隔变异性相关性非常好，因此验证了视频分析在此方面的有效性。乙酰胆碱处理导致心率和收缩强度降低，但对间隔变异性的影响可忽略不计。然而，收缩强度的变异性分析显示，对照组织和乙酰胆碱处理组织之间的样本熵和 Higuchi 维数存在显著差异。因此，所提出的高速摄像机技术可能代表一种非侵入性工具，它允许进行长时间记录，以检测大范围尺度上搏动行为的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/5ac791b2e332/fphys-09-00546-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/0758bbd8a721/fphys-09-00546-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/d41d99101ff7/fphys-09-00546-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/f32d164df4df/fphys-09-00546-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/8a951f88313a/fphys-09-00546-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/388d721960f9/fphys-09-00546-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/0a50ff1b1b5f/fphys-09-00546-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/c11e8f85e119/fphys-09-00546-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/43091f532b54/fphys-09-00546-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/f6d43f01fa11/fphys-09-00546-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/5ac791b2e332/fphys-09-00546-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/0758bbd8a721/fphys-09-00546-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/d41d99101ff7/fphys-09-00546-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/f32d164df4df/fphys-09-00546-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/8a951f88313a/fphys-09-00546-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/388d721960f9/fphys-09-00546-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/0a50ff1b1b5f/fphys-09-00546-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/c11e8f85e119/fphys-09-00546-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/43091f532b54/fphys-09-00546-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/f6d43f01fa11/fphys-09-00546-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/5968354/5ac791b2e332/fphys-09-00546-g0010.jpg

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