Sun Kaibao, Cui Jianfei, Wang Bo, Jiang Tao, Chen Zhongwei, Cong Fei, Zhuo Yan, Liang Shuli, Xue Rong, Yu Xinguang, Chen Lin
State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Neuroradiology. 2018 Aug;60(8):785-794. doi: 10.1007/s00234-018-2040-2. Epub 2018 Jun 5.
This study was conducted to determine the benefit of magnetic resonance imaging (MRI) at 7 T in detecting structural lesions and previously unidentified abnormalities in patients with tuberous sclerosis complex (TSC).
Thirteen patients with TSC (8-36 years, seven males) previously diagnosed by 3 T MRI underwent additional imaging at 7 T, which included T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE), T2-weighted turbo spin echo (TSE), SPACE fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), white matter suppressed (WM-suppressed), and gray-white matter tissue border enhancement (GW-TBE) MPRAGE sequences. Subtle lesions, tuberal morphology, and perituberal cortex abnormalities were examined and compared to those observed at 3 T MRI using standard sequences.
Improved visualization of TSC lesions was achieved in all subjects at 7 T compared to 3 T imaging, and three subjects received resective surgery. The 7 T T1- and T2-weighted images had high spatial resolution and provided a clear delineation of the perituberal cortex. SWI revealed abnormal blood vessel morphology. WM-suppressed and GW-TBE protocols, adjusted specifically for TSC imaging, aided in visualizing lesions and uncovered more extensive subtle lesions and abnormalities beyond the conventionally detected tubers.
Due to its high spatial resolution and powerful new imaging protocols, 7 T MRI provided a better evaluation of subtle lesions and perituberal details compared with conventional MRI at 3 T, with potential implications for diagnosis and operative treatment of TSC and its related epilepsy.
本研究旨在确定7T磁共振成像（MRI）在检测结节性硬化症（TSC）患者的结构病变和先前未发现的异常方面的益处。
13例先前经3T MRI诊断的TSC患者（8 - 36岁，7例男性）接受了7T的额外成像检查，包括T1加权磁化准备快速梯度回波（MPRAGE）、T2加权快速自旋回波（TSE）、SPACE液体衰减反转恢复（FLAIR）、磁敏感加权成像（SWI）、白质抑制（WM抑制）和灰白质组织边界增强（GW - TBE）MPRAGE序列。检查了细微病变、结节形态和结节周围皮质异常，并与使用标准序列在3T MRI上观察到的情况进行比较。
与3T成像相比，所有受试者在7T时TSC病变的可视化效果均得到改善，3例受试者接受了切除手术。7T的T1加权和T2加权图像具有高空间分辨率，清晰显示了结节周围皮质。SWI显示了异常的血管形态。专门为TSC成像调整的WM抑制和GW - TBE方案有助于病变的可视化，并发现了传统检测的结节之外更广泛的细微病变和异常。
由于其高空间分辨率和强大的新成像方案，与传统的3T MRI相比，7T MRI能更好地评估细微病变和结节周围细节，对TSC及其相关癫痫的诊断和手术治疗具有潜在意义。
