单酮姜黄素类化合物对致龋菌的抗菌活性
Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria.
作者信息
Vieira Tatiana M, Dos Santos Isabella A, Silva Thayná S, Martins Carlos H G, Crotti Antônio E M
机构信息
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, CEP 14040-901, Ribeirão Preto, SP, Brazil.
Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Av. Dr. Armando Salles de Oliveira, 201 - Parque Universitário, CEP 14404600, Franca, SP, Brazil.
出版信息
Chem Biodivers. 2018 Aug;15(8):e1800216. doi: 10.1002/cbdv.201800216. Epub 2018 Jul 15.
We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC = 50 μg/ml) and Streptococcus mitis (MIC = 50 μg/ml) as well as moderate activity against S. sanguinis (MIC = 100 μg/ml), Lactobacillus casei (MIC = 100 μg/ml), and Streptococcus salivarius (MIC = 200 μg/ml). Results indicated higher activity of compound 10 than that of its bis-β-diketone analog. Additionally, compounds 3a (1,5-bis(4-methylphenyl)pentan-3-one) and 7b (1,5-bis(4-bromophenyl)pentan-3-ol) were moderately active against S. mitis (MIC = 100 μg/ml) and S. salivarus (MIC = 200 μg/ml).
我们根据最低抑菌浓度（MIC）值，评估了25种单酮类姜黄素（MKC）对一组代表性致龋菌的抗菌活性。姜黄素A（10）对变形链球菌（MIC = 50μg/ml）和缓症链球菌（MIC = 50μg/ml）显示出有前景的活性，对血链球菌（MIC = 100μg/ml）、干酪乳杆菌（MIC = 100μg/ml）和唾液链球菌（MIC = 200μg/ml）显示出中等活性。结果表明化合物10的活性高于其双β-二酮类似物。此外，化合物3a（1,5-双（4-甲基苯基）戊-3-酮）和7b（1,5-双（4-溴苯基）戊-3-醇）对缓症链球菌（MIC = 100μg/ml）和唾液链球菌（MIC = 200μg/ml）具有中等活性。
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