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药物难治性癫痫的外科治疗结果

Outcome of Surgical Treatment in Medically Refractory Epilepsy.

作者信息

Khan A H, Islam K M T, Barman K K, Barua K K, Abraham M

出版信息

Bangladesh Med Res Counc Bull. 2015 Dec;41(3):121-124. doi: 10.3329/bmrcb.v41i3.29887.

DOI:10.3329/bmrcb.v41i3.29887
PMID:29870166
Abstract

The aim of epilepsy surgery is not only to control seizures but also to curtail future adverse neurological sequelae and improve quality of life. Epilepsy surgery is a viable treatment option for selected cases of medically refractory epilepsy. A study was carried out with a series of 34 cases who underwent epilepsy surgery at Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India during July, 2010 to December, 2010. Clinical features, operative procedures and early response to treatment were cha'racterized. Among 34 cases, main clinical manifestation was recurrent seizures. All cases were evaluated by Video Electro Encephalogram (EEG) & Magnetic Resonance Imaging (MRI) of brain with epilepsy protocol. Nearly 58% cases were diagnosed as mesial temporal sclerosis who were treated by anterior temporal lobectomy (ATL) with amygdalohippocampectomy (AH). Excision of epileptogenic foci was confirmed by preoperative Electro Cardiogram. Early response to surgery was good. However, a prolonged longitudinal follow up is essential for accurate assessment of seizure outcome.

摘要

癫痫手术的目的不仅是控制癫痫发作,还在于减少未来不良的神经后遗症并提高生活质量。对于某些药物难治性癫痫病例,癫痫手术是一种可行的治疗选择。对2010年7月至2010年12月期间在印度喀拉拉邦的斯里·奇特拉·蒂鲁纳尔医学科学与技术研究所接受癫痫手术的34例患者进行了一项研究。对其临床特征、手术过程及早期治疗反应进行了描述。34例患者中,主要临床表现为癫痫反复发作。所有病例均采用癫痫方案进行视频脑电图(EEG)及脑部磁共振成像(MRI)评估。近58%的病例被诊断为内侧颞叶硬化,接受了前颞叶切除术(ATL)及杏仁核海马切除术(AH)治疗。术前心电图证实了致痫灶的切除。手术早期反应良好。然而,为了准确评估癫痫发作结果,长期的纵向随访至关重要。

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