Department of Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Department of Geratology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Semin Liver Dis. 2018 May;38(2):170-180. doi: 10.1055/s-0038-1646949. Epub 2018 Jun 5.
The unique liver immune microenvironment favors resistance to inflammation that promotes normal physiological function. At the same time, it endows the liver with tolerogenic properties that may promote pathological processes. Hepatic dendritic cells (HDCs) initiate and orchestrate immune responses depending on signals they receive from the local environment and are thought to contribute to liver tolerance. Thus, HDCs facilitate impaired T cell responses that are observed in persistent hepatitis C virus (HCV) infection, hepatocellular carcinoma progression, and liver allograft transplantation. HDCs also participate in anti-inflammatory responses in liver ischemia-reperfusion injury (IRI). Moreover, they promote the regression of fibrosis from various fibrogenic liver injuries. These findings suggest that HDCs regulate intrahepatic immune responses, allowing the liver to maintain homeostasis and integrity even under pathological conditions. This review focuses on the tolerogenic properties of HDCs based on recent research and in relation to liver disease pathogenesis and its therapy.
独特的肝脏免疫微环境有利于抵抗炎症，从而促进正常的生理功能。同时，它赋予肝脏耐受特性，可能促进病理过程。肝脏树突状细胞 (HDC) 根据其从局部环境中接收到的信号启动和协调免疫反应，被认为有助于肝脏耐受。因此，HDC 促进持续丙型肝炎病毒 (HCV) 感染、肝细胞癌进展和肝移植中观察到的受损 T 细胞反应。HDC 还参与肝缺血再灌注损伤 (IRI) 中的抗炎反应。此外，它们促进各种纤维发生性肝损伤的纤维化消退。这些发现表明，HDC 调节肝内免疫反应，使肝脏即使在病理条件下也能维持其体内平衡和完整性。这篇综述基于最近的研究，重点关注 HDC 的耐受特性，以及与肝病发病机制及其治疗的关系。
