Herfurth K, Busch M, Gröne H J, Wolf G
Klinik für Innere Medizin III, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
Zelluläre und Molekulare Pathologie (G130), Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Deutschland.
Internist (Berl). 2018 Nov;59(11):1204-1207. doi: 10.1007/s00108-018-0446-x.
Treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a well-established therapeutic strategy for various autoimmune diseases. However, little is known about renal complications and possible causality of renal injury due to this treatment. The following case of a patient with psoriasis demonstrates the difficulties in classifying renal complications of anti-TNF-α therapy versus kidney involvement caused by the underlying disease.
使用肿瘤坏死因子α(TNF-α)抑制剂进行治疗是针对各种自身免疫性疾病的一种成熟治疗策略。然而,对于这种治疗引起的肾脏并发症以及肾损伤的可能因果关系知之甚少。以下一名银屑病患者的病例展示了在区分抗TNF-α治疗的肾脏并发症与基础疾病所致肾脏受累方面的困难。