Lan Y G, Chen K, Zhang Z X, Ye Y H, Zhang Z G
The First Department of Otorhinolaryngology, Meizhou People's Hospital, Meizhou, 514000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 May;32(10):770-773. doi: 10.13201/j.issn.1001-1781.2018.10.011.
To remove the immune function of children with obstructive sleep apnea hypopnea syndrome by resection of adenoids and tonsillar. The fasting peripheral venous blood of children with OSAHS and healthy children were collected. The lymphocyte subsets, NK cells and immunoglobulin levels were compared between the two groups. The fasting blood samples of OSAHS children were collected again after 2d, 30d, 60d and 90d after operation. The changes of lymphocyte subsets, NK cells and immunoglobulin levels were observed after operation. Before operation, at the 0.05 test level, it was not yet clear that the levels of IgG, IgM, IgA, NK, CD3+, CD4+ and CD8+ in OSAHS children were significantly different from those in the control group. The levels of IgA, CD3+ and CD4+ decreased significantly in children at 2d and OSAHS after operation, and IgG, IgM, IgA, NK, CD3+ and IgA continued to rise after 60d until ninetieth day after operation. There is no statistical disorder of immune level in children with OSAHS compared with healthy children. The implementation of adenoidectomy and tonsillectomy in children with OSAHS, the level of immunity in 90 days can be restored to the preoperative level.
通过切除腺样体和扁桃体来去除阻塞性睡眠呼吸暂停低通气综合征患儿的免疫功能。收集阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿和健康儿童的空腹外周静脉血。比较两组患儿的淋巴细胞亚群、自然杀伤（NK）细胞及免疫球蛋白水平。对OSAHS患儿在术后2天、30天、60天和90天再次采集空腹血样，观察术后淋巴细胞亚群、NK细胞及免疫球蛋白水平的变化。术前，在0.05检验水准下，尚不清楚OSAHS患儿的IgG、IgM、IgA、NK、CD3⁺、CD4⁺和CD8⁺水平与对照组有显著差异。术后2天OSAHS患儿的IgA、CD3⁺和CD4⁺水平显著下降，术后60天直至90天IgG、IgM、IgA、NK、CD3⁺和IgA持续上升。与健康儿童相比，OSAHS患儿的免疫水平无统计学紊乱。对OSAHS患儿实施腺样体切除术和扁桃体切除术后，90天免疫水平可恢复至术前水平。
