亚硝酸叔丁酯促进的炔烃氧化分子间磺酰胺化反应：由炔基胺和亚磺酸合成取代磺酰基吡咯。

tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids.

作者信息

Qi Zhenjie, Jiang Yong, Wang Yanyan, Yan Rulong

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , 730000 , Gansu China.

School of Chemistry and Chemical Engineering , Yangtze Normal University , Chongqing , 400000 China.

出版信息

J Org Chem. 2018 Aug 3;83(15):8636-8644. doi: 10.1021/acs.joc.8b00741. Epub 2018 Jun 14.

DOI:10.1021/acs.joc.8b00741

PMID:29873495

Abstract

tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.

摘要

开发了一种亚硝酸叔丁酯促进的炔烃氧化分子间磺酰胺化反应，该反应通过串联加成/环化反应，由炔基胺和亚磺酸合成取代的磺酰基吡咯。以亚硝酸叔丁酯作为氧化剂，该反应进行良好，可在无金属催化的情况下，以中等至良好的产率生成各种取代的磺酰基吡咯。