心肌重构能否成为心肌铁负荷的有用替代预测指标？一项 3D 超声心动图多中心研究。
Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic multicentric study.
机构信息
Pediatric, Cardiology Unit, Pediatrics Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt.
Children's Cancer Hospital, Egypt 57357, Cairo, Egypt.
出版信息
Pediatr Blood Cancer. 2018 Oct;65(10):e27272. doi: 10.1002/pbc.27272. Epub 2018 Jun 6.
The relationship between myocardial iron load and eccentric myocardial remodeling remains an under-investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2* with a 100% sensitivity and specificity (cut-off value of 0.34) to discriminate between patients with and without myocardial iron overload.
心肌铁负荷与偏心性心肌重构之间的关系仍是一个研究不足的领域；人们认为重构与纤维化关系更为密切。本研究旨在确定重构的测量指标是否可以作为心肌铁的预测因子。为此，对 60 例地中海贫血患者进行了 3D 超声心动图和心脏 MRI 心肌弛豫度（T2*）检查。结果显示，心肌铁负荷患者的 3D 衍生的球形指数显著升高。它与 T2*呈正相关，具有 100%的灵敏度和特异性（截断值为 0.34），可区分有无心肌铁过载的患者。
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