Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Cell Metab. 2018 Jun 5;27(6):1157-1158. doi: 10.1016/j.cmet.2018.05.013.
In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an overall improvement in healthy male volunteers but no improvement in male patients with diabetes.
在小鼠中，白细胞介素-6（IL-6）通过刺激胰高血糖素样肽 1（GLP-1）的分泌来改善葡萄糖耐量。在本期《细胞代谢》中，Lang Lehrskov 等人（2018）表明，IL-6 输注具有 GLP-1 依赖性和非依赖性作用，对葡萄糖耐量有相反的影响，导致健康男性志愿者的整体改善，但对糖尿病男性患者没有改善。
