Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Wuhan Medical and Health Center for Women and Children, Wuhan, Hubei, People's Republic of China.
Chemosphere. 2018 Feb;193:1157-1163. doi: 10.1016/j.chemosphere.2017.11.121. Epub 2017 Nov 23.
Prior studies have suggested the reproductive effects of nickel; however, few epidemiological studies have investigated the associations of maternal exposure to nickel with preterm delivery. To investigate prenatal exposure to nickel as a risk factor for preterm delivery (< 37 weeks) in a large birth cohort. A total of 7291 pregnant women participated in the study were recruited between September 2012 and October 2014 in the longitudinal Healthy Baby Cohort (HBC) in Wuhan, China. Inductively Coupled Plasma Mass Spectrometry was employed to examine levels of nickel in urine from pregnant women collected before labor. The median urinary creatinine-corrected nickel was 5.05 creatinine μg/g with an inter-quartile range of 2.65-9.51 creatinine μg/g. We adjusted for potential confounders and found that each doubling in concentration of maternal urinary nickel was associated with an increase of 16% in adjusted odds ratios (ORs) for preterm delivery (95% CI: 1.08, 1.24). The associations were consistent for both spontaneous and iatrogenic preterm delivery. Our findings suggest that higher maternal urinary nickel concentrations were associated with an increased risk of preterm delivery.
先前的研究表明镍具有生殖毒性；然而，很少有流行病学研究调查母亲暴露于镍与早产之间的关联。为了在一个大型的出生队列中调查产前暴露于镍是否是早产（<37 周）的一个危险因素。2012 年 9 月至 2014 年 10 月，共有 7291 名孕妇在中国武汉的纵向健康婴儿队列（HBC）中参加了这项研究。采用电感耦合等离子体质谱法检测孕妇分娩前尿液中的镍水平。孕妇尿液中校正肌酐的镍中位数为 5.05 肌酐μg/g，四分位间距为 2.65-9.51 肌酐μg/g。我们调整了潜在的混杂因素，发现母体尿液中镍浓度每增加一倍，校正后的早产比值比（OR）就增加 16%（95%CI：1.08，1.24）。自发性和医源性早产的关联都是一致的。我们的研究结果表明，母体尿液中镍浓度较高与早产风险增加有关。
