白三烯生物合成阻滞剂与磷酸二酯酶抑制剂对支气管高反应性患者疗效的比较
Comparison of Effect of Leukotriene Biosynthesis Blockers and Inhibitors of Phosphodiesterase Enzyme in Patients with Bronchial Hyperreactivity.
作者信息
Morina Naim, Haliti Arsim, Iljazi Ali, Islami Drita, Bexheti Sadi, Bozalija Adnan, Islami Hilmi
机构信息
Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Kosovo Occupational Health Institute, Gjakovo, Kosovo.
出版信息
Open Access Maced J Med Sci. 2018 Apr 23;6(5):777-781. doi: 10.3889/oamjms.2018.187. eCollection 2018 May 20.
AIM
Blocking effect of leukotriene biosynthesis-zileuton and blocking the effect of phosphodiesterase enzyme-diprophylline in the treatment of patients with bronchial asthma and bronchial increased reactivity, and tiotropium bromide as an antagonist of the muscarinic receptor studied in this work.
METHODS
Parameters of the lung function are determined with Body plethysmography. The resistance of the airways (Raw) was registered and measured was intrathoracic gas volume (ITGV), and specific resistance (SRaw) was also calculated. For the research, administered was zileuton (tabl. 600 mg) and diprophylline (tabl. 150 mg).
RESULTS
Two days after in-house administration of leukotriene biosynthesis blocker-zileuton (4 x 600 mg orally), on the day 3 initial values of patients measured and afterwards administered 1 tablet of zileuton, and again measured was Raw and ITGV, after 60, 90 and 120 min. and calculated was SRaw; (p < 0.01). Diprophylline administered 7 days at home in a dose of (2 x 150 mg orally), on the day 8 to same patients administered 1 tablet of diprophylline, and performed measurements of Raw, ITGV, after 60, 90 and 120 min, and calculated the SRaw (p < 0.05). Treatment of the control group with tiotropium bromide - antagonist of the muscarinic receptor (2 inh. x 0.18 mcg), is effective in removal of the increased bronchomotor tonus, by also causing the significant decrease of the resistance (Raw), respectively of the specific resistance (SRaw), (p < 0.05).
CONCLUSION
Effect of zileuton in blocking of leukotriene biosynthesis is not immediate after oral administration, but the effect seen on the third day of cys-LTs' inhibition, and leukotriene B4 (LTB4) and A4 (LTA4) in patients with bronchial reactivity and bronchial asthma, which is expressed with a high significance, (p < 0.01). Blockage of phosphodiesterase enzyme-diprophylline decreases the bronchial reactivity, which is expressed with a moderate significance, (p < 0.05).
目的
研究白三烯生物合成阻滞剂齐留通的阻断作用、磷酸二酯酶抑制剂二羟丙茶碱的阻断作用在支气管哮喘和支气管反应性增强患者治疗中的效果，以及噻托溴铵作为毒蕈碱受体拮抗剂的作用。
方法
采用体容积描记法测定肺功能参数。记录气道阻力（Raw），测量胸腔内气体容积（ITGV），并计算比气道阻力（SRaw）。研究中，给予齐留通（片剂，600毫克）和二羟丙茶碱（片剂，150毫克）。
结果
在院内口服白三烯生物合成阻滞剂齐留通（4×600毫克）两天后，于第3天测量患者初始值，之后给予1片齐留通，分别在60、90和120分钟后再次测量Raw和ITGV，并计算SRaw；（p<0.01）。二羟丙茶碱在家中以（2×150毫克口服）的剂量服用7天，在第8天对同一患者给予1片二羟丙茶碱，在60、90和120分钟后测量Raw、ITGV，并计算SRaw（p<0.05）。用毒蕈碱受体拮抗剂噻托溴铵（2吸×0.18微克）治疗对照组，可有效消除支气管运动张力增加，同时使阻力（Raw）和比气道阻力（SRaw）显著降低，（p<0.05）。
结论
口服齐留通后，其对白三烯生物合成的阻断作用并非立即显现，而是在抑制半胱氨酰白三烯（cys-LTs）的第3天出现效果，且在支气管反应性和支气管哮喘患者中对白三烯B4（LTB4）和A4（LTA4）的抑制作用具有高度显著性，（p<0.01）。磷酸二酯酶抑制剂二羟丙茶碱可降低支气管反应性，具有中度显著性，（p<0.05）。
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