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Psychotic disorders induced by antiepileptic drugs in people with epilepsy.癫痫患者中由抗癫痫药物诱发的精神障碍。
Brain. 2016 Oct;139(Pt 10):2668-2678. doi: 10.1093/brain/aww196. Epub 2016 Aug 8.
2
Psychosis as Harbinger of Phenytoin Toxicity.精神病作为苯妥英钠毒性的先兆
Toxicol Int. 2015 Jan-Apr;22(1):160-1. doi: 10.4103/0971-6580.172272.
3
Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process.左乙拉西坦治疗下的非癫痫性发作:强制性正常化过程的病例报告。
Neuropsychiatr Dis Treat. 2014 May 23;10:959-64. doi: 10.2147/NDT.S60089. eCollection 2014.
4
Treating patients with medically resistant epilepsy.治疗药物难治性癫痫患者。
Neurol Clin Pract. 2011 Dec;1(1):14-23. doi: 10.1212/CPJ.0b013e31823d07d1.
5
Epilepsy and psychiatric comorbidity: a nationally representative population-based study.癫痫与精神共病:一项全国代表性的基于人群的研究。
Epilepsia. 2012 Jun;53(6):1095-103. doi: 10.1111/j.1528-1167.2012.03500.x. Epub 2012 May 11.
6
Evidence for shared susceptibility to epilepsy and psychosis: a population-based family study.癫痫和精神病共享易感性的证据:一项基于人群的家族研究。
Biol Psychiatry. 2012 May 1;71(9):836-9. doi: 10.1016/j.biopsych.2012.01.011. Epub 2012 Feb 25.
7
Adjunctive levetiracetam in children, adolescents, and adults with primary generalized seizures: open-label, noncomparative, multicenter, long-term follow-up study.左乙拉西坦辅助治疗儿童、青少年和成人原发性全面性癫痫发作:开放标签、非对照、多中心、长期随访研究。
Epilepsia. 2012 Jan;53(1):111-9. doi: 10.1111/j.1528-1167.2011.03300.x. Epub 2011 Nov 2.

苯妥英增强左乙拉西坦治疗:一例出现精神病性症状的强制正常化病例。

Phenytoin Augmentation of Levetiracetam Treatment: A Case of Forced Normalization With Emergence of Psychosis.

作者信息

Esang Michael, Kotapati Vijaya Padma, Ahmed Saeed

机构信息

Behavioral Health Sciences, Nassau University Medical Center, East Meadow, USA.

Psychiatry, Manhattan Psychiatric Center.

出版信息

Cureus. 2018 Apr 5;10(4):e2432. doi: 10.7759/cureus.2432.

DOI:10.7759/cureus.2432
PMID:29876154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5988159/
Abstract

Forced normalization is the emergence of psychoses following stabilization of seizures in an uncontrolled epileptic patient. The current study is a case of forced normalization, a phenomenon characterized by normalization of electroencephalogram (EEG) findings and resolution of seizures. This case report is unique and rare because the patient meets the diagnostic merit of forced normalization, which occurred due to a nonconventional method of seizure control management. We discuss the recognition and differential diagnoses of such cases, understanding the phenomenon of forced normalization and treatment strategies, which may help clinicians in their clinical practice.

摘要

强制性正常化是指在未得到控制的癫痫患者癫痫发作稳定后出现精神病性症状。本研究是一例强制性正常化病例,该现象的特征是脑电图(EEG)结果正常化及癫痫发作缓解。本病例报告独特且罕见,因为该患者符合强制性正常化的诊断标准,其发生是由于一种非传统的癫痫控制管理方法。我们讨论此类病例的识别与鉴别诊断、对强制性正常化现象的理解及治疗策略,这可能有助于临床医生的临床实践。