Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.
Hormones (Athens). 2019 Mar;18(1):55-63. doi: 10.1007/s42000-018-0032-6. Epub 2018 Jun 6.
Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropriately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective. Conventional treatment with vitamin D analogues and calcium salts is no longer the only available treatment, since replacement treatment with PTH(1-84) has recently been approved for the disease. However, the optimal treatment schedule is yet to be defined.
甲状旁腺功能减退症是一种相对罕见的内分泌疾病，其特征是血清钙水平下降低或甲状旁腺激素 (PTH) 分泌不当。其他主要的实验室发现包括低钙血症、不适当的正常或高尿钙排泄以及低尿磷排泄伴高磷血症。甲状旁腺功能减退症的管理应根据每个个体病例进行调整，这使得它在日常临床实践中具有挑战性。在这篇综述中，我们从临床角度出发，旨在关注甲状旁腺功能减退症的诊断方法和疾病的治疗挑战。维生素 D 类似物和钙盐的常规治疗不再是唯一可用的治疗方法，因为最近已批准使用 PTH(1-84)替代治疗该疾病。然而，最佳治疗方案仍有待确定。
