Molecular Oncology and Therapeutics, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Hum Cell. 2018 Oct;31(4):271-281. doi: 10.1007/s13577-018-0211-4. Epub 2018 Jun 6.
Scirrhous gastric cancer (SGC) exhibits aggressiveness of the rapid infiltrating tumor cells with abundant fibroblasts. Experimental studies using SGC cell lines have obtained useful information about this cancer. Our literature search divulged a total of 18 SGC cell lines; two cell lines were established from primary SGC and the other lines were established from a metastatic lesion of SGC. Fibroblast growth factor receptor 2 (FGFR2) and transforming growth factor-beta receptor (TβR) are linked to the rapid development of SGC. Cross-talk between the cancer cells and cancer-associated fibroblasts (CAFs) has been shown to contribute to the progression of SGC. Chemokine (C-X-C motif) receptor 1 (CXCR1) from SGC cells might be associated with the abundant CAFs in cancer microenvironments. The in vivo models established using SGC cell lines are expected to serve as a useful tool for the development of drugs such as FGFR2 inhibitors, TβR inhibitors, and CXCR1 inhibitors, which might be promising as SGC treatments. However, the number of available SGC cell lines is insufficient for the clarification of the entire biologic behavior of SGC. Since the mechanisms responsible for the characteristic aggressiveness of SGC are not fully elucidated, the establishment of new SGC cell lines could help clarify the biological behavior of SGC and contribute to its treatment.
硬癌（SGC）表现为富含成纤维细胞的快速浸润肿瘤细胞的侵袭性。使用 SGC 细胞系的实验研究已经获得了有关这种癌症的有用信息。我们的文献检索共发现了 18 种 SGC 细胞系；其中两个细胞系是从原发性 SGC 建立的，其他细胞系是从 SGC 的转移病变建立的。成纤维细胞生长因子受体 2（FGFR2）和转化生长因子-β受体（TβR）与 SGC 的快速发展有关。已经表明癌细胞与癌相关成纤维细胞（CAFs）之间的串扰有助于 SGC 的进展。来自 SGC 细胞的趋化因子（C-X-C 基序）受体 1（CXCR1）可能与富含癌症微环境中的 CAFs 有关。使用 SGC 细胞系建立的体内模型有望成为开发 FGFR2 抑制剂、TβR 抑制剂和 CXCR1 抑制剂等药物的有用工具，这些药物可能是治疗 SGC 的有前途的方法。然而，可用的 SGC 细胞系数量不足以阐明 SGC 的整个生物学行为。由于导致 SGC 特征性侵袭性的机制尚未完全阐明，因此建立新的 SGC 细胞系有助于阐明 SGC 的生物学行为并为其治疗做出贡献。
