National Center for Sports Medicine, Warsaw, Poland.
Department of Social Medicine and Public Health, Warsaw Medical University, Warsaw, Poland.
Adv Exp Med Biol. 2018;1108:49-54. doi: 10.1007/5584_2018_223.
Being frequent travelers, the elite athletes are advised to undergo an influenza vaccination. The aim of the study was to describe the antibody response to repeated trivalent, inactivated, split influenza vaccine, of different antigenic content, recommended for the Northern and the Southern Hemisphere, administered to sportsmen before the Olympic Games in Brasil in 2016. Fourteen athletes were included in the study. For both A/California/7/209/pdm09 A/H1N1/ antigen and A/Switzerland/971593/2013/A/H3N2/ antigen, higher seroconversion rates were obtained after the first than the second vaccination (10.2 vs. 1.5 and 10.6 vs. 3.0, respectively; p < 0.05 both). Conversion rates for B/Phuket/3073/2013, B/Brisbane/60/2008, and A/HongKong/4801/2014/A/H3N2/ antigens were lower. Nonetheless, the protection rate was greater than 70% for all antigens contained in both vaccines. The proportion of individuals demonstrating a high level of both protection rate and response rate was greater after the first than the second vaccination. We conclude that the immunological response after influenza vaccination is good in elite athletes and remains so after a second influenza vaccination required due to a different vaccine composition recommended for different hemispheres.
作为经常旅行的人，建议精英运动员接种流感疫苗。本研究的目的是描述不同抗原含量的三价、灭活、分裂流感疫苗在巴西 2016 年奥运会前对运动员进行重复接种后的抗体反应，该疫苗推荐用于南北半球。共有 14 名运动员纳入研究。对于 A/California/7/209/pdm09 A/H1N1/ 抗原和 A/Switzerland/971593/2013/A/H3N2/ 抗原，第一次接种后的血清转化率均高于第二次接种（分别为 10.2%比 1.5%和 10.6%比 3.0%；均<0.05）。B/Phuket/3073/2013、B/Brisbane/60/2008 和 A/HongKong/4801/2014/A/H3N2/ 抗原的转化率较低。然而，两种疫苗中包含的所有抗原的保护率均大于 70%。第一次接种后，同时具有高保护率和高反应率的个体比例大于第二次接种。我们的结论是，精英运动员接种流感疫苗后的免疫反应良好，即使由于不同的半球推荐使用不同的疫苗成分而进行第二次流感疫苗接种，反应仍保持良好。
