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[自身免疫性脑炎]

[Autoimmune encephalitis].

作者信息

Guasp M, Arino H, Dalmau J

机构信息

Hospital Clinic-IDIBAPS, Universidad de Barcelona, Barcelona, Espana.

University of Pennsylvania School of Medicine, Philadelphia (Pennsylvania), EE.UU.

出版信息

Rev Neurol. 2018 Jun 5;66(s02):S1-S6.

Abstract

Autoimmune encephalitis are a new category of inflammatory diseases of the central nervous system mediated by antibodies that attack neurotransmitter or protein receptors on the surface of neurons. The clinical syndromes are complex and are associated with manifestations that vary according to the type of antibody that is associated. The autoimmune response can start due to the presence of a tumour or viral infection, but in many case the cause remains unknown. In paediatrics, the most frequent autoimmune encephalitis is that associated with NMDA glutamate receptor antibodies (or anti-NMDA encephalitis). In children and teenagers, the initial symptoms are usually different from those of adults and the disease is rarely associated with tumours. In this article, in addition to anti-NMDA encephalitis, the general aspects of autoimmune encephalitis are reviewed and the most common questions asked about treatment of these diseases are addressed.

摘要

自身免疫性脑炎是一类由攻击神经元表面神经递质或蛋白质受体的抗体介导的中枢神经系统炎症性疾病。其临床综合征复杂,且与根据相关抗体类型而有所不同的表现相关。自身免疫反应可能因肿瘤或病毒感染的存在而引发,但在许多情况下病因仍不明。在儿科,最常见的自身免疫性脑炎是与N-甲基-D-天冬氨酸(NMDA)谷氨酸受体抗体相关的脑炎(或抗NMDA脑炎)。在儿童和青少年中,初始症状通常与成人不同,且该疾病很少与肿瘤相关。在本文中,除了抗NMDA脑炎外,还综述了自身免疫性脑炎的一般情况,并解答了关于这些疾病治疗的最常见问题。

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