Wendling Daniel
Bull Acad Natl Med. 2015 Oct;199(7):1177-1185.
Spondyloarthritis is a chronic inflammatory disease, whose pathogeny involves microbial agents, genetic factors and the gut, leading to inflammation in several target tissues. The Th7 pathway corresponds to polarization of CD4 naive cells towards Thi 7 cells (produ- cing predominantly IL-17 and IL-22) under the influence of IL-23, completing the IL-23IThJ 7 axis. This pathway is activated and involved at several levels in spondyloarth- ritis : microbial contact (microbiota and dysbiosis), HLA-B27 (misfolding) and gut inflammation. IL-23 receptor expressing cells were found in enthuses of animal model, and migrating from gut to blood, bone marrow and joint in humans. The involvement of this pathway allows insight into targeted therapies against IL-I 7 or IL-23 in spondyloarthritis.
脊柱关节炎是一种慢性炎症性疾病，其发病机制涉及微生物因子、遗传因素和肠道，导致多个靶组织发生炎症。Th7途径是指在IL-23的影响下，CD4幼稚细胞向Th17细胞（主要产生IL-17和IL-22）极化，从而形成IL-23/Th17轴。该途径在脊柱关节炎的多个层面被激活并参与其中：微生物接触（微生物群和生态失调）、HLA-B27（错误折叠）和肠道炎症。在动物模型的病灶中发现了表达IL-23受体的细胞，在人类中这些细胞从肠道迁移至血液、骨髓和关节。该途径的参与有助于深入了解针对脊柱关节炎中IL-17或IL-23的靶向治疗。
