核黄素的一种代谢产物与2,3,7,8-四氯二苯并对二恶英（TCDD）受体结合。
A metabolite of riboflavin binds to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor.
作者信息
Kurl R N, Villee C A
出版信息
Pharmacology. 1985;30(5):241-4. doi: 10.1159/000138073.
PMID:2987979
Abstract
A cytosolic receptor to which TCDD binds with high affinity has been reported in a number of rodent tissues, but the endogenous/natural ligand is not known. However, lumichrome, a metabolite of riboflavin, competed with 3H-TCDD for binding to the cytosolic receptor. Neither riboflavin nor riboflavin-5-phosphate competed for binding to the TCDD receptor in rat liver cytosol. Lumichrome is the first known endogenous chemical in the rat to exhibit affinity for the TCDD receptor.
摘要
在许多啮齿动物组织中都报道了一种能与2,3,7,8-四氯二苯并对二恶英（TCDD）高亲和力结合的胞质受体，但内源性/天然配体尚不清楚。然而，核黄素的一种代谢产物光色素能与3H-TCDD竞争结合胞质受体。核黄素和核黄素-5-磷酸都不能竞争大鼠肝细胞溶胶中TCDD受体的结合。光色素是大鼠中首个已知的对TCDD受体具有亲和力的内源性化学物质。
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