Yin Zhenzhen, Wang Youyou, Wu Yuemei, Zhang Ximei, Wang Fengming, Wang Peiguo, Tao Zhen, Yuan Zhiyong
Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, People's Republic of China.
Cancer Manag Res. 2018 May 29;10:1359-1364. doi: 10.2147/CMAR.S151945. eCollection 2018.
The objective of the study was to describe the age distribution and to evaluate the role of prognostic value of age on survival in patients diagnosed with olfactory neuroblastoma (ONB). A population-based retrospective analysis was conducted.
The population-based study of patients in the Surveillance, Epidemiology, and End Results (SEER) tumor registry, who were diagnosed with ONB from 1973 to 2014, were retrospectively analyzed.
The cohort included 876 patients with a median age of 54 years. There was a unimodal distribution of age and ONBs most frequently occurred in the fifth to sixth decades of life. Kaplan-Meier analysis demonstrated overall survival (OS) and cancer-specific survival (CSS) rates of 69% and 78% at 5 years. Multivariable Cox regression analysis showed that age, SEER stage, and surgery were independent prognostic factors for CSS. The risk of overall death and cancer-specific death increased 3.1% and 1.6% per year, respectively. Patients aged >60 years presented significantly poor OS and CSS compared with patients aged ≤60 years, even in patients with loco-regional disease or in those treated with surgery.
This study highlights the growing evidence that there is a unimodal age distribution of ONB and that age is an important adverse prognostic factor.
本研究的目的是描述年龄分布，并评估年龄对嗅神经母细胞瘤（ONB）患者生存的预后价值作用。进行了一项基于人群的回顾性分析。
对监测、流行病学和最终结果（SEER）肿瘤登记处中1973年至2014年被诊断为ONB的患者进行基于人群的研究，并进行回顾性分析。
该队列包括876例患者，中位年龄为54岁。年龄呈单峰分布，ONB最常发生在50至60岁之间。Kaplan-Meier分析显示，5年总生存率（OS）和癌症特异性生存率（CSS）分别为69%和78%。多变量Cox回归分析表明，年龄、SEER分期和手术是CSS的独立预后因素。全因死亡风险和癌症特异性死亡风险分别每年增加3.1%和1.6%。与年龄≤60岁的患者相比，年龄>60岁的患者OS和CSS显著较差，即使是局部区域疾病患者或接受手术治疗的患者也是如此。
本研究突出了越来越多的证据，即ONB存在单峰年龄分布，且年龄是一个重要的不良预后因素。
