Kondratiuk T P, babich L G, Osipenko A A, Bychenok S F, Kurskiĭ M D
Vopr Med Khim. 1985 Mar-Apr;31(2):55-9.
Myometrium of female rabbits at the state of functional rest contained 260 pmoles of cAMP per g of tissue and 25 pmoles cGMP. In dynamics of pregnancy content of cAMP was increased up to 400 pmoles/g within the second half of pregnancy; the content of cGMP was decreased down to 10 pmoles/g. During labor content of cAMP and of cGMP became minimal; within the postnatal period concentration of cAMP was increased up to the values observed in the antenatal period and the content of cGMP was unaltered. Under these conditions the content of cAMP, cGMP and the activity of corresponding soluble phosphodiesterases were similarly altered. The regulatory subunit of protein kinase of the type I (RI) was shown to possess two sites for cAMP binding and RII--one site. The data obtained suggest that cyclic nucleotides are important for regulation of the myometrium functional state.
处于功能静止状态的雌性兔子宫肌层每克组织含260皮摩尔环磷酸腺苷（cAMP）和25皮摩尔环磷酸鸟苷（cGMP）。在妊娠动态过程中，妊娠后半期cAMP含量增加至400皮摩尔/克；cGMP含量降至10皮摩尔/克。分娩时cAMP和cGMP含量降至最低；产后cAMP浓度升至产前观察到的值，cGMP含量未改变。在这些条件下，cAMP、cGMP含量及相应可溶性磷酸二酯酶活性发生类似变化。已表明I型蛋白激酶（RI）的调节亚基有两个cAMP结合位点，RII有一个位点。所得数据表明环核苷酸对子宫肌层功能状态的调节很重要。
