Vendelbo Johansen L
Acta Radiol Oncol. 1985 Mar-Apr;24(2):113-6. doi: 10.3109/02841868509134372.
Alopecia is a common side effect of cancer chemotherapy, especially in combination with regimens with doxorubicin (Adriamycin). The effect of scalp hypothermia in connection with chemotherapy was evaluated as hair protection in 61 women with disseminated breast carcinoma, where earlier treatment routines had caused wig-requiring alopecia in nearly all patients. The cooling was performed with a gel-helmet (Hypotherm Gel-Kap). Of the 61 patients, 47 (77%) had no or slight, not wig-demanding hair loss, and 14 (23%) had severe (wig-demanding) hair loss. Seven patients had liver dysfunction; in 5 of these severe hair loss was observed; 2 had slight hair loss. Eighty-three per cent of the patients with normal liver function had no hair loss. Treatment tolerance was found to be good, and side effects were minimal. The method is found to be simple, effective and inexpensive, though still not technically optimal.
脱发是癌症化疗常见的副作用，尤其是在联合使用阿霉素（阿霉素）的治疗方案时。对61例弥漫性乳腺癌女性患者，评估了头皮低温疗法联合化疗对头发的保护作用，这些患者之前的治疗常规几乎使所有患者都出现了需要佩戴假发的脱发情况。使用凝胶头盔（Hypotherm Gel-Kap）进行冷却。61例患者中，47例（77%）没有或仅有轻微脱发，不需要佩戴假发，14例（23%）出现严重（需要佩戴假发）脱发。7例患者有肝功能障碍；其中5例观察到严重脱发；2例有轻微脱发。肝功能正常的患者中有83%没有脱发。发现治疗耐受性良好，副作用最小。该方法简单、有效且成本低廉，尽管在技术上仍非最佳。
