Galaris D, Isberg B, Ahlberg N E, Rydström J
Acta Radiol Oncol. 1985 Mar-Apr;24(2):177-80. doi: 10.3109/02841868509134383.
The cardiotoxic effect of daunorubicin was investigated using cultured heart cells from neonatal rat hearts. Exposure of the cells to low but toxic concentrations of daunorubicin led to drastically altered permeability properties of the plasma membrane as measured by release of lactate dehydrogenase. Simultaneously, 99Tcm-gluconate, an isotope complex used in scintigraphic imaging of myocardial infarcts, was accumulated in the cells. The results suggest that daunorubicin-induced cardiac damage may be estimated by isotope uptake.
利用新生大鼠心脏的培养心肌细胞研究了柔红霉素的心脏毒性作用。将细胞暴露于低浓度但有毒的柔红霉素中，通过乳酸脱氢酶的释放来测定，这导致质膜的通透性特性发生了显著改变。同时，用于心肌梗死闪烁成像的同位素复合物锝-99m葡萄糖酸盐在细胞中蓄积。结果表明，柔红霉素诱导的心脏损伤可通过同位素摄取来评估。
