Hatjis C G, Rose J C, Pippitt C, Swain M
Am J Obstet Gynecol. 1985 Jun 1;152(3):315-6. doi: 10.1016/s0002-9378(85)80219-2.
To investigate whether treatment with valproic acid in pregnancy decreases adrenocorticotropic hormone and cortisol secretion, we measured their concentrations in maternal and umbilical cord blood from a patient receiving valproic acid. We found them to be normal. Valproic acid may not decrease adrenocorticotropic hormone/cortisol levels in pregnant patients or their fetuses.
为研究孕期使用丙戊酸是否会降低促肾上腺皮质激素和皮质醇分泌,我们测量了一名接受丙戊酸治疗患者的母血和脐带血中这两种激素的浓度。我们发现其浓度正常。丙戊酸可能不会降低孕妇及其胎儿体内的促肾上腺皮质激素/皮质醇水平。