Leslie Dan Faculty of Pharmacy, University of Toronto, Barrie, Canada.
Last Mile, Holte, Denmark.
Cardiovasc Diabetol. 2018 Jun 8;17(1):83. doi: 10.1186/s12933-018-0728-6.
BACKGROUND: Cardiovascular disease (CVD) is a common comorbidity in type 2 diabetes (T2DM). CVD's prevalence has been growing over time. PURPOSE: To estimate the current prevalence of CVD among adults with T2DM by reviewing literature published within the last 10 years (2007-March 2017). METHODS: We searched Medline, Embase, and proceedings of major scientific meetings for original research documenting the prevalence of CVD in T2DM. CVD included stroke, myocardial infarction, angina pectoris, heart failure, ischemic heart disease, cardiovascular disease, coronary heart disease, atherosclerosis, and cardiovascular death. No restrictions were placed on country of origin or publication language. Two reviewers independently searched for articles and extracted data, adjudicating results through consensus. Data were summarized descriptively. Risk of bias was examined by applying the STROBE checklist. RESULTS: We analyzed data from 57 articles with 4,549,481 persons having T2DM. Europe produced the most articles (46%), followed by the Western Pacific/China (21%), and North America (13%). Overall in 4,549,481 persons with T2DM, 52.0% were male, 47.0% were obese, aged 63.6 ± 6.9 years old, with T2DM duration of 10.4 ± 3.7 years. CVD affected 32.2% overall (53 studies, N = 4,289,140); 29.1% had atherosclerosis (4 studies, N = 1153), 21.2% had coronary heart disease (42 articles, N = 3,833,200), 14.9% heart failure (14 studies, N = 601,154), 14.6% angina (4 studies, N = 354,743), 10.0% myocardial infarction (13 studies, N = 3,518,833) and 7.6% stroke (39 studies, N = 3,901,505). CVD was the cause of death in 9.9% of T2DM patients (representing 50.3% of all deaths). Risk of bias was low; 80 ± 12% of STROBE checklist items were adequately addressed. CONCLUSIONS: Globally, overall CVD affects approximately 32.2% of all persons with T2DM. CVD is a major cause of mortality among people with T2DM, accounting for approximately half of all deaths over the study period. Coronary artery disease and stroke were the major contributors.
背景：心血管疾病（CVD）是 2 型糖尿病（T2DM）的常见合并症。CVD 的患病率一直在上升。
目的：通过回顾过去 10 年（2007 年 3 月至 2017 年）发表的文献，评估 T2DM 成人 CVD 的当前患病率。
方法：我们检索了 Medline、Embase 和主要科学会议的会议记录，以获取记录 T2DM 中 CVD 患病率的原始研究。CVD 包括中风、心肌梗死、心绞痛、心力衰竭、缺血性心脏病、心血管疾病、冠心病、动脉粥样硬化和心血管死亡。对来源国或出版语言没有限制。两名审查员独立搜索文章并提取数据，通过共识解决结果。数据以描述性方式进行总结。应用 STROBE 清单检查偏倚风险。
结果：我们分析了来自 57 篇文章的数据，这些文章共有 4549481 名 T2DM 患者。欧洲发表的文章最多（46%），其次是西太平洋/中国（21%）和北美（13%）。在总共 4549481 名患有 T2DM 的患者中，52.0%为男性，47.0%为肥胖，年龄为 63.6±6.9 岁，T2DM 病程为 10.4±3.7 年。总体而言，CVD 影响了 32.2%的患者（53 项研究，N=4289140）；29.1%有动脉粥样硬化（4 项研究，N=1153），21.2%有冠心病（42 项研究，N=3833200），14.9%心力衰竭（14 项研究，N=601154），14.6%心绞痛（4 项研究，N=354743），10.0%心肌梗死（13 项研究，N=3518833）和 7.6%中风（39 项研究，N=3901505）。CVD 是 T2DM 患者死亡的原因，占 T2DM 患者死亡人数的 9.9%（占所有死亡人数的 50.3%）。偏倚风险较低；STROBE 清单项目中有 80±12%得到了充分解决。
结论：在全球范围内，总体 CVD 影响了大约 32.2%的所有 T2DM 患者。CVD 是 T2DM 患者死亡的主要原因，占研究期间所有死亡人数的近一半。冠状动脉疾病和中风是主要原因。
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