动脉导管未闭的可变作用。

Variable role of patent ductus arteriosus.

机构信息

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan.

出版信息

Semin Fetal Neonatal Med. 2018 Aug;23(4):273-277. doi: 10.1016/j.siny.2018.05.002. Epub 2018 Jun 1.

DOI:10.1016/j.siny.2018.05.002

PMID:29884402

Abstract

Although patent ductus arteriosus is essential in fetal life, interventions to close or minimize the adverse hemodynamic effects associated with the left-to-right shunt are often needed after birth, especially in extremely premature infants. However, there are clinical conditions where maintaining patency of the ductus is essential for survival. In this article we discuss use of prostaglandin E in the management of congenital heart defects, pulmonary hypertension and left ventricular failure in early neonatal period.

摘要

虽然动脉导管在胎儿期是必需的，但出生后通常需要干预来关闭或最小化与左向右分流相关的不良血液动力学效应，尤其是在极早产儿中。然而，在某些临床情况下，保持动脉导管通畅对于生存至关重要。本文讨论了前列腺素 E 在新生儿期先天性心脏缺陷、肺动脉高压和左心衰竭的治疗中的应用。