Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
Inserm, U1016, Institut Cochin, 75014 Paris, France; CNRS, UMR8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Sorbonne université, Inserm, Saint-Antoine research center, 75012 Paris, France.
Clin Res Hepatol Gastroenterol. 2019 Feb;43(1):5-11. doi: 10.1016/j.clinre.2018.05.001. Epub 2018 Jun 5.
The CRISPR technology is rapidly transforming the field of liver research by its versatility and easy use. In vivo gene editing of hepatocytes in adult mice can be achieved using a broad toolbox for both fundamental research and development of therapeutic strategies for future clinical applications. Recent studies showed that CRISPR has a real potential to treat hereditary liver diseases as well as virally induced pathologies. This short review recapitulates very recent advancements regarding the use of CRISPR in liver research and therapy.
CRISPR 技术凭借其多功能性和易用性，正在迅速改变肝脏研究领域。利用广泛的工具包，可对成年小鼠的肝细胞进行体内基因编辑，这既适用于基础研究，也适用于未来临床应用的治疗策略的开发。最近的研究表明，CRISPR 具有治疗遗传性肝脏疾病和病毒诱导病理的真正潜力。本文简要综述了 CRISPR 在肝脏研究和治疗中的最新进展。
