King G S, Cottingham L G, Hughes R E, Ratliff P D
Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
J Clin Pharm Ther. 2018 Dec;43(6):903-905. doi: 10.1111/jcpt.12719. Epub 2018 Jun 9.
Prothrombin complex concentrate (PCC) is a plasma-derived concentrate used to replenish clotting factors. There are limited recommendations for treating coagulopathy induced by direct oral anticoagulants (DOAC). Data are limited regarding both total dose and repeated dosing with this population.
We describe a case of an adult patient anticoagulated with apixaban who received two 35 unit/kg doses of PCC resulting in suspected pulmonary embolism.
Treatment of DOAC-induced bleeding remains an "off-label" indication for PCC. Additional doses should be given with caution if given at all and patients monitored closely.
凝血酶原复合物浓缩剂（PCC）是一种用于补充凝血因子的血浆源性浓缩剂。关于治疗直接口服抗凝剂（DOAC）引起的凝血病的建议有限。关于该人群的总剂量和重复给药的数据均有限。
我们描述了一例接受阿哌沙班抗凝治疗的成年患者，该患者接受了两剂35单位/千克的PCC，结果疑似发生肺栓塞。
PCC用于治疗DOAC引起的出血仍然属于“超说明书用药”指征。如需再次给药，应谨慎使用，并密切监测患者。
