DiRenzo Dana, McMahan Zsuzsanna H, Desai Naman S, Manno Rebecca, Petri Michelle
Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building, Center Tower, Suite 4100, Baltimore, MD 21224, USA.
Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiologic Science, The Johns Hopkins Hospital, Phipps B-100, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Case Rep Rheumatol. 2018 May 17;2018:5862912. doi: 10.1155/2018/5862912. eCollection 2018.
The differential diagnosis for a focal brain lesion in a patient with systemic lupus erythematosus (SLE) is broad and includes infection, malignancy, and vascular and inflammatory etiologies. One rarely considered vascular pathology is cerebral venous thrombosis (CVT), which is often associated with a delay in diagnosis because of variable presentation and rare incidence. We present the case of a young woman with a new discrete brain lesion that appeared in the context of highly active SLE and was ultimately diagnosed with a CVT. We provide a literature review for diagnosis and management of cerebral venous thrombosis, a potentially serious complication of untreated systemic lupus erythematosus.
系统性红斑狼疮(SLE)患者出现局灶性脑病变时,鉴别诊断范围广泛,包括感染、恶性肿瘤以及血管和炎症性病因。一种很少被考虑到的血管病变是脑静脉血栓形成(CVT),由于其表现多样且发病率低,常常导致诊断延迟。我们报告了一例年轻女性病例,该患者在高度活跃的SLE背景下出现了一个新的孤立性脑病变,最终被诊断为CVT。我们对脑静脉血栓形成的诊断和管理进行了文献综述,脑静脉血栓形成是未经治疗的系统性红斑狼疮的一种潜在严重并发症。