酮色林不能预防促肾上腺皮质激素诱导的绵羊高血压。
Ketanserin does not prevent ACTH-induced hypertension in sheep.
作者信息
Nelson M A, Coghlan J P, Denton D A, Whitworth J A, Scoggins B A
出版信息
Clin Exp Pharmacol Physiol. 1985 Mar-Apr;12(2):155-9. doi: 10.1111/j.1440-1681.1985.tb02318.x.
Abstract
The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.
摘要
已对血清素（5-羟色胺，5HT）在绵羊促肾上腺皮质激素（ACTH）诱导的高血压发病机制中的作用进行了研究。正常血压和高血压绵羊对注射5HT（0.1 - 30微克/千克）的升压反应相似。用5HT2受体拮抗剂酮色林预先治疗对ACTH给药所产生的高血压发展没有影响。
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