Prescott R W, Kendall-Taylor P, Weightman D R, Watson M J, Ratcliffe W A
Clin Endocrinol (Oxf). 1984 Feb;20(2):137-42. doi: 10.1111/j.1365-2265.1984.tb00068.x.
The role of serotonin in the prolactin, growth hormone, ACTH and cortisol responses to hypoglycaemia has been investigated in normal subjects using a selective serotonin (5HT2) receptor antagonist, ketanserin. Circulating concentrations of these hormones were measured after administration of insulin (0.1 units/kg body weight iv) to eight normal male subjects with and without simultaneous iv ketanserin (10 mg). Plasma glucose fell to less than 2.0 mmol/1 in all subjects and was unaffected by ketanserin. Ketanserin induced a 50% decrease in the serum prolactin response to hypoglycaemia, 45 and 60 min after administration of insulin (increase in serum prolactin at 60 min: 1145 +/- 295 mU/l without ketanserin; 558 +/- 176 mU/l with ketanserin, P less than 0.05). The peak ACTH response was reduced by 30% (95.3 +/- 33.6 ng/l without ketanserin; 60.0 +/- 22.9 ng/l with ketanserin, P less than 0.05) but the plasma cortisol response was not significantly altered. The serum growth hormone response was unaffected by serotonin blockade. These findings suggest that serotonin, probably acting through 5HT2 receptors, is involved in the stimulation of prolactin and ACTH release but not in the release of growth hormone, during insulin induced hypoglycaemia.
使用选择性5-羟色胺（5HT2）受体拮抗剂酮色林，在正常受试者中研究了5-羟色胺在催乳素、生长激素、促肾上腺皮质激素（ACTH）和皮质醇对低血糖反应中的作用。对8名正常男性受试者静脉注射胰岛素（0.1单位/千克体重），同时或不同时静脉注射酮色林（10毫克），然后测量这些激素的循环浓度。所有受试者的血浆葡萄糖均降至低于2.0毫摩尔/升，且不受酮色林影响。酮色林使胰岛素注射后45和60分钟时血清催乳素对低血糖的反应降低了50%（60分钟时血清催乳素升高：未用酮色林时为1145±295毫单位/升；用酮色林时为558±176毫单位/升，P<0.05）。促肾上腺皮质激素峰值反应降低了30%（未用酮色林时为95.3±33.6纳克/升；用酮色林时为60.0±22.9纳克/升，P<0.05），但血浆皮质醇反应未显著改变。血清生长激素反应不受5-羟色胺阻断的影响。这些发现表明，在胰岛素诱导的低血糖期间，5-羟色胺可能通过5HT2受体发挥作用，参与催乳素和促肾上腺皮质激素释放的刺激，但不参与生长激素的释放。
