Spence C D, Coghlan J P, Denton D A, Fei D T, Mills E H, Whitworth J A, Scoggins B A
Clin Exp Pharmacol Physiol. 1985 Mar-Apr;12(2):181-5. doi: 10.1111/j.1440-1681.1985.tb02321.x.
The role of the renin-angiotensin system in the onset of ACTH-induced hypertension was examined in five conscious sheep. Captopril infusion alone (15 mg/kg per day) for 2 days produced a small fall in blood pressure. After 2 days of captopril ACTH was infused (20 micrograms/kg per day) for 3 days together with captopril. The blood pressure and electrolyte effects of ACTH administration were not modified by captopril pretreatment. These experiments establish that angiotensin II is not important in the onset of ACTH-induced hypertension in sheep.
在五只清醒绵羊中研究了肾素-血管紧张素系统在促肾上腺皮质激素（ACTH）诱导的高血压发病中的作用。单独输注卡托普利（每天15毫克/千克）2天导致血压略有下降。在输注卡托普利2天后，与卡托普利一起输注ACTH（每天20微克/千克）3天。卡托普利预处理并未改变ACTH给药对血压和电解质的影响。这些实验表明，血管紧张素II在绵羊ACTH诱导的高血压发病中并不重要。
