缺氧诱导因子-1α在鼻咽癌中的预后价值：一项荟萃分析

Prognostic value of hypoxia-inducible factor-1 alpha in nasopharyngeal carcinoma: a meta-analysis.

作者信息

Xie Wenji, Liu Lihui, He Haixia, Yang Kaixuan

机构信息

Department of Radiation Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Int J Biol Markers. 2018 Jun 1:1724600818778756. doi: 10.1177/1724600818778756.

DOI:10.1177/1724600818778756

PMID:29888634

Abstract

BACKGROUND

Over the past 5 years, many studies have reported the prognostic value of hypoxia-inducible factor-1 alpha (HIF-1α) in nasopharyngeal carcinoma. However, the results have not reached a consensus until now. Therefore, we performed this meta-analysis to investigate the influence of HIF-1α expression on the prognosis and clinical characteristics in nasopharyngeal carcinoma.

METHODS

We searched PubMed, the Cochrane Library, Embase (via Ovid interface), Web of Science, and China National Knowledge Infrastructure electronic databases from their establishment to 6 December 2017. We calculated the hazard ratio (HR) and the odds ratio (OR) to assess the prognostic and clinicopathological values of HIF-1α, respectively. Q test and I statistic were applied to evaluate heterogeneity. We also conducted publication bias and sensitivity analyses.

RESULTS

A total of 18 studies with 1476 patients were included in our meta-analysis. We found HIF-1α expression was associated with poor overall survival (HR=1.77; 95% confidence interval (CI) 1.35, 2.32; P<0.001), poor progression-free survival (HR=1.72; 95% CI 1.22, 2.44; P=0.002), a higher rate of lymph node metastasis (OR=3.81; 95% CI 2.60, 5.58, P<0.001), and more advanced tumor stage (OR=2.98; 95% CI 1.79, 4.97; P<0.001).

CONCLUSIONS

Our study demonstrated that HIF-1α could be an appropriate prognostic biomarker for nasopharyngeal carcinoma patients.

摘要

背景

在过去5年中，许多研究报道了缺氧诱导因子-1α（HIF-1α）在鼻咽癌中的预后价值。然而，迄今为止结果尚未达成共识。因此，我们进行了这项荟萃分析，以研究HIF-1α表达对鼻咽癌预后和临床特征的影响。

方法

我们检索了PubMed、Cochrane图书馆、Embase（通过Ovid界面）、Web of Science和中国国家知识基础设施电子数据库，检索时间从各数据库建立至2017年12月6日。我们分别计算风险比（HR）和比值比（OR），以评估HIF-1α的预后价值和临床病理价值。采用Q检验和I统计量评估异质性。我们还进行了发表偏倚和敏感性分析。

结果

我们的荟萃分析共纳入18项研究，涉及1476例患者。我们发现HIF-1α表达与总生存期差（HR=1.77；95%置信区间（CI）1.35，2.32；P<0.001）、无进展生存期差（HR=1.72；95%CI 1.22，2.44；P=0.002）、更高的淋巴结转移率（OR=3.81；95%CI 2.60，5.58，P<0.001）以及更晚期的肿瘤分期（OR=2.98；95%CI 1.79，4.97；P<0.001）相关。