Bartelt R N, Altmeyer P, Stöhr L, Holzmann H
Derm Beruf Umwelt. 1985;33(2):50-5.
The basal secretion of proteo-hormones alpha-MSH and ACTH in plasma as well as the changes of the plasma concentrations following UV A-whole-body irradiation were investigated on 40 young male volunteers with different pigmentation levels (Caucasians: skin types I, II, III. Blacks: skin type VI). Significantly lower mean basic values of alpha-MSH and ACTH of light-haired persons in comparison with dark-haired and black persons (p less than 0,05) were demonstrated. We observed furthermore a significant increase of these proteo-hormones (alpha-MSH: skin type I: 26,7%, skin type II: 22,7%) in persons less pigmented within a short time after UV A whole-body irradiation in contrast to the more pigmented volunteers. These results prove a cutaneous peripheral sensor for UV A-rays, reacting with a different sensitivity depending on disposition and inducing endocrinological reactions. How this cutaneous-hypothalamic-pituitary stimulus mediation functions in detail is not completely revealed up to now. In what respect the present results, which can be explained as a consequence of evolutionary development, have a connection with the induction of melanoma remains to be seen.
对40名不同色素沉着水平的年轻男性志愿者（白种人：皮肤类型I、II、III；黑人：皮肤类型VI）进行了研究，以观察血浆中蛋白激素α-促黑素（alpha-MSH）和促肾上腺皮质激素（ACTH）的基础分泌以及全身紫外线A照射后血浆浓度的变化。结果显示，浅色头发的人的α-MSH和ACTH平均基础值显著低于深色头发的人和黑人（p<0.05）。此外，我们观察到，与色素沉着较多的志愿者相比，全身紫外线A照射后，色素沉着较少的人在短时间内这些蛋白激素显著增加（α-MSH：皮肤类型I：26.7%，皮肤类型II：22.7%）。这些结果证明了皮肤对紫外线A射线的外周感受器，其反应敏感性因个体差异而异，并引发内分泌反应。目前尚不完全清楚这种皮肤-下丘脑-垂体刺激介导的具体作用机制。从进化发展的角度来看，目前的结果与黑色素瘤的诱发有何关联仍有待观察。
