腺苷可增加豚鼠结肠带平滑肌中的细胞内钙储备。

Adenosine increases an internal calcium store in the smooth muscle of guinea-pig taenia coli.

作者信息

Frischknecht R, Ferrero J D

出版信息

Eur J Pharmacol. 1985 Mar 26;110(1):109-12. doi: 10.1016/0014-2999(85)90035-4.

Abstract

The effect of adenosine on an internal calcium store which can be released by carbachol to produce a transient contraction in Ca2+-free solution was investigated in the taenia depolarized by high K+. The carbachol contraction in Ca2+-free solution was increased by the preceding application of adenosine (3 X 10(-5) to 10(-3) M), an effect which was mimicked by ATP, but not by the slowly degradable analog alpha, beta-methylene ATP. The P1-purinoceptor antagonist 8-phenyltheophylline inhibited the increase caused by adenosine without modifying the carbachol contraction in controls. It is concluded that stimulation of an extracellular P1-purinoceptor increases an internal store of calcium, which might contribute to the relaxation induced by adenosine in the taenia.

摘要

在高钾使绦虫肌膜去极化的条件下，研究了腺苷对一种细胞内钙储备的作用，这种钙储备可被卡巴胆碱释放，从而在无钙溶液中产生短暂收缩。在无钙溶液中，预先应用腺苷（3×10⁻⁵至10⁻³M）可增强卡巴胆碱引起的收缩，ATP可模拟此效应，但缓慢降解的类似物α,β-亚甲基ATP则无此作用。P1嘌呤受体拮抗剂8-苯基茶碱可抑制腺苷引起的增强作用，而不改变对照组中卡巴胆碱的收缩。结论是，细胞外P1嘌呤受体的刺激增加了细胞内钙储备，这可能是腺苷引起绦虫肌松弛的原因之一。