Dinelli Maria Isabel S, Dos Santos Amélia M N, Weckx Lily Y, de Moraes-Pinto Maria Isabel
Division of Pediatric Infectious Diseases, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
Division of Neonatal Medicine, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
Transpl Infect Dis. 2018 Oct;20(5):e12951. doi: 10.1111/tid.12951. Epub 2018 Jun 25.
In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tacrolimus or cyclosporine) and 31 control infants not exposed to these medications. No differences in adverse events were detected after rotavirus vaccination at 2 and 4 months.
子宫内暴露于免疫抑制药物可能是轮状病毒疫苗的禁忌证，但这可能因免疫抑制方案而异。我们评估了24名肾移植母亲所生的婴儿，这些母亲在孕期暴露于3种免疫抑制剂（泼尼松、硫唑嘌呤以及他克莫司或环孢素），并评估了31名未暴露于这些药物的对照婴儿。在2个月和4个月接种轮状病毒疫苗后，未检测到不良事件有差异。
