Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
Int J Mol Sci. 2018 Jun 8;19(6):1706. doi: 10.3390/ijms19061706.
Infection with high-risk human papillomavirus (HPV) has been linked to several human cancers, the most prominent of which is cervical cancer. The integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression. The most well-studied cellular targets of the viral oncogenes E6 and E7 are p53 and pRb, respectively. However, recent research has demonstrated the ability of these two viral factors to target many more cellular factors, including proteins which regulate epigenetic marks and splicing changes in the cell. These have the ability to exert a global change, which eventually culminates to uncontrolled proliferation and carcinogenesis.
高危型人乳头瘤病毒（HPV）感染与多种人类癌症有关，其中最突出的是宫颈癌。病毒基因组整合到宿主基因组中是病毒癌基因 E6 和 E7 实现持续表达的方式之一。病毒癌基因 E6 和 E7 最受研究关注的细胞靶标分别是 p53 和 pRb。然而，最近的研究表明，这两种病毒因子能够靶向许多更多的细胞因子，包括调节细胞表观遗传标记和剪接变化的蛋白质。这些因子能够发挥全局变化，最终导致不受控制的增殖和癌变。
