Tanaka Takako Imai, Alawi Faizan
Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Robert Schattner Center #215, Philadelphia, PA 19104, USA.
Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, 328B, Philadelphia, PA 19104, USA.
Dent Clin North Am. 2018 Jan;62(1):111-120. doi: 10.1016/j.cden.2017.08.008. Epub 2017 Oct 7.
Human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) comprises approximately 25% of all head and neck cancers (head and neck squamous cell carcinoma, HNSCC). Epidemiologic studies have shown a dramatic increase of HPV-OPSCC in the past 2 decades, whereas tobacco-related HNSCC rates are decreasing worldwide. The distinctions between HPV-OPSCC and oral cavity cancers are now reflected in the most recent editions of the World Health Organization Classification of Tumors of the Head and Neck and the American Joint Committee on Cancer Staging Manual, respectively. This review describes current understanding of the link between HPV infection and OPSCC.
人乳头瘤病毒相关的口咽鳞状细胞癌（HPV-OPSCC）约占所有头颈癌（头颈鳞状细胞癌，HNSCC）的25%。流行病学研究表明，在过去20年中，HPV-OPSCC的发病率急剧上升，而全球范围内与烟草相关的HNSCC发病率正在下降。HPV-OPSCC与口腔癌之间的区别现在分别反映在世界卫生组织最新版的《头颈部肿瘤分类》和美国癌症联合委员会分期手册中。本综述描述了目前对HPV感染与OPSCC之间联系的理解。
