Robotics Program, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 34141, Korea.
Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Daejeon 34141, Korea.
Sensors (Basel). 2018 Jun 10;18(6):1896. doi: 10.3390/s18061896.
Here, MineLoC is described as a pipeline developed to generate 3D printable models of master templates for Lab-on-a-Chip (LoC) by using a popular multi-player sandbox game “Minecraft”. The user can draw a simple diagram describing the channels and chambers of the Lab-on-a-Chip devices with pre-registered color codes which indicate the height of the generated structure. MineLoC converts the diagram into large chunks of blocks (equal sized cube units composing every object in the game) in the game world. The user and co-workers can simultaneously access the game and edit, modify, or review, which is a feature not generally supported by conventional design software. Once the review is complete, the resultant structure can be exported into a stereolithography (STL) file which can be used in additive manufacturing. Then, the Lab-on-a-Chip device can be fabricated by the standard protocol to produce a Lab-on-a-Chip. The simple polydimethylsiloxane (PDMS) device for the bacterial growth measurement used in the previous research was copied by the proposed method. The error calculation by a 3D model comparison showed an accuracy of 86%. It is anticipated that this work will facilitate more use of 3D printer-based Lab-on-a-Chip fabrication, which greatly lowers the entry barrier in the field of Lab-on-a-Chip research.
这里描述了一个名为 MineLoC 的管道，它是使用流行的多玩家沙盒游戏“Minecraft”生成用于芯片实验室（Lab-on-a-Chip，LoC）的 3D 可打印模型主模板的工具。用户可以用预先注册的颜色代码绘制一个简单的图表，描述芯片实验室设备的通道和腔室，这些颜色代码表示生成结构的高度。MineLoC 将图表转换为游戏世界中的大块块（组成游戏中每个物体的等大小立方单元）。用户和同事可以同时访问游戏并进行编辑、修改或审查，这是传统设计软件通常不支持的功能。审查完成后，可以将生成的结构导出为立体光刻（stereolithography，STL）文件，可用于增材制造。然后，可通过标准协议制造芯片实验室设备，以制造芯片实验室。使用之前研究中使用的简单聚二甲基硅氧烷（polydimethylsiloxane，PDMS）设备复制了所提出的方法。通过 3D 模型比较进行的误差计算显示出 86%的准确性。预计这项工作将促进更多基于 3D 打印机的芯片实验室制造的使用，这极大地降低了芯片实验室研究领域的进入门槛。
