Yan Shouyi, Zhao Wenxin, Wang Bo, Zhang Liyong
1 Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
Surg Innov. 2018 Aug;25(4):357-363. doi: 10.1177/1553350618779703. Epub 2018 Jun 12.
The study aims to evaluate the clinic feasibility of rapid parathyroid hormone (PTH) detection and nano-carbon technology in preoperative diagnosis and localization of parathyroid adenoma.
With the guidance of ultrasound, the operator performed the parathyroid puncture and tested the PTH value by using a PTH test kit, and then injected nano-carbon into parathyroid adenoma as a marker to observe whether the parathyroid adenoma was stained black during the final operation. Meanwhile, a part of excised specimen was made into homogenate and detected rapidly again by using the PTH test kit. The remaining was confirmed by intraoperative frozen pathological examination.
The sensitivity (12/12) of preoperative diagnosis was significantly higher than that of ultrasound (6/12), magnetic resonance imaging (7/12), and MIBI (9/12). During the operation, we found that the inner part of the parathyroid adenoma was stained black, and the PTH value of the specimen homogenate confirmed as parathyroid adenoma was more than 3000 pg/mL.
This novel technology, as a very positive method for localization of parathyroid adenoma, plays an important role in guaranteeing the surgical reliability of parathyroid adenoma with help of nano-carbon technology.
本研究旨在评估快速甲状旁腺激素（PTH）检测及纳米碳技术在甲状旁腺腺瘤术前诊断及定位中的临床可行性。
在超声引导下，操作者进行甲状旁腺穿刺，使用PTH检测试剂盒检测PTH值，然后向甲状旁腺腺瘤内注入纳米碳作为标记物，观察最终手术时甲状旁腺腺瘤是否被染成黑色。同时，将部分切除标本制成匀浆，再次使用PTH检测试剂盒进行快速检测。其余标本通过术中冰冻病理检查进行确诊。
术前诊断的敏感性（12/12）显著高于超声（6/12）、磁共振成像（7/12）和MIBI（9/12）。手术过程中，我们发现甲状旁腺腺瘤内部被染成黑色，确诊为甲状旁腺腺瘤的标本匀浆PTH值大于3000 pg/mL。
这项新技术作为一种非常有效的甲状旁腺腺瘤定位方法，借助纳米碳技术在保证甲状旁腺腺瘤手术可靠性方面发挥着重要作用。
