TRIO 和 F-肌动蛋白结合蛋白在人类疾病中的新兴作用。
Emerging roles of TRIO and F-actin-binding protein in human diseases.
机构信息
Department of Pharmacology, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, 35015, South Korea.
出版信息
Cell Commun Signal. 2018 Jun 11;16(1):29. doi: 10.1186/s12964-018-0237-y.
TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP variants are broadly classified as variant-1 or - 4 and do not share exons. TRIOBP variant-5 contains all exons. Earlier studies indicated that TRIOBP-4/5 mutation is a pivotal element of autosomal recessive nonsyndromic hearing loss. However, recent studies provide clues that TRIOBP variants are associated with other human diseases including cancer and brain diseases. In this review, recent functional studies focusing on TRIOBP variants and its possible disease models are described.
三聚体蛋白（TRIO）和 F-肌动蛋白结合蛋白（TRIOBP）也被称为 Tara，最初被分离为一种细胞骨架重塑蛋白。TRIOBP-1 对于调节 F-肌动蛋白丝的重组非常重要。TRIOBP 变体广泛分为变体-1 或-4，它们不共享外显子。TRIOBP 变体-5 包含所有外显子。早期研究表明，TRIOBP-4/5 突变是常染色体隐性非综合征性听力损失的关键因素。然而，最近的研究提供了线索，表明 TRIOBP 变体与其他人类疾病有关，包括癌症和脑部疾病。在这篇综述中，描述了最近针对 TRIOBP 变体及其可能的疾病模型的功能研究。
Zotero 插件