Baak J P
Histopathology. 1985 Apr;9(4):437-44. doi: 10.1111/j.1365-2559.1985.tb02826.x.
In a group of 65 patients with invasive ductal breast cancer with adequate follow-up for at least 5 years, the prognostic significance of nucleolar area morphometry was investigated. In general, non-survivors have larger and more pleomorphic nucleoli. A value of the standard deviation of the nucleolar area above 2.49 micron2 was almost exclusively found in non-survivors. This is the more interesting because several of these patients had a low mitotic activity index and small tumours, some of these having negative lymph nodes. Without nucleolar morphometry these patients would have been included in a favourable prognosis group. Although the sensitivity of nucleolar morphometry is low, the method can be used as an additional prognostic indicator. This is more important as nucleoli can in principle be automatically measured with digital image processing computers.
在一组65例浸润性导管乳腺癌患者中，对其进行了至少5年的充分随访，研究了核仁面积形态测量的预后意义。一般来说，非幸存者的核仁更大且多形性更强。核仁面积标准差大于2.49平方微米的值几乎只在非幸存者中出现。这一点更值得关注，因为其中一些患者有较低的有丝分裂活性指数和较小的肿瘤，部分患者淋巴结阴性。如果没有核仁形态测量，这些患者会被归入预后良好组。尽管核仁形态测量的敏感性较低，但该方法可作为一个额外的预后指标。这一点更为重要，因为原则上核仁可以用数字图像处理计算机自动测量。
