Richard Sabine, Flamant Frédéric
Institut de Génomique Fonctionnelle de Lyon, INRA USC 1370, Université de Lyon, Université Lyon 1, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Lyon, France.
Front Endocrinol (Lausanne). 2018 May 28;9:265. doi: 10.3389/fendo.2018.00265. eCollection 2018.
Alterations in maternal thyroid physiology may have deleterious consequences on the development of the fetal brain, but the underlying mechanisms remain elusive, hampering the development of appropriate therapeutic strategies. The present review sums up the contribution of genetically modified mouse models to this field. In particular, knocking out genes involved in thyroid hormone (TH) deiodination, transport, and storage has significantly improved the picture that we have of the economy of TH in the fetal brain and the underlying genetic program. These data pave the way for future studies to bridge the gap in knowledge between thyroid physiology and brain development.
母体甲状腺生理的改变可能会对胎儿大脑发育产生有害影响，但其潜在机制仍不清楚，这阻碍了适当治疗策略的发展。本综述总结了转基因小鼠模型在该领域的贡献。特别是，敲除参与甲状腺激素（TH）脱碘、转运和储存的基因，显著改善了我们对胎儿大脑中TH代谢及其潜在遗传程序的认识。这些数据为未来研究填补甲状腺生理学和大脑发育之间的知识空白铺平了道路。
