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COVID-19 出院后，2 型脱碘酶基因 Thr92Ala 多态性与抑郁症相关。

The Thr92Ala polymorphism in the type 2 deiodinase gene is linked to depression in patients with COVID-19 after hospital discharge.

机构信息

Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.

Department of Internal Medicine, University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil.

出版信息

Front Endocrinol (Lausanne). 2024 Jun 7;15:1366500. doi: 10.3389/fendo.2024.1366500. eCollection 2024.

DOI:10.3389/fendo.2024.1366500
PMID:38911040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11190161/
Abstract

BACKGROUND

The Thr92Ala-DIO2 polymorphism has been associated with clinical outcomes in hospitalized patients with COVID-19 and neuropsychiatric diseases. This study examines the impact of the Thr92Ala-DIO2 polymorphism on neuropsychological symptoms, particularly depressive symptoms, in patients who have had moderate to severe SARS-CoV-2 infection and were later discharged.

METHODS

Our prospective cohort study, conducted from June to August 2020, collected data from 273 patients hospitalized with COVID-19. This included thyroid function tests, inflammatory markers, hematologic indices, and genotyping of the Thr92Ala-DIO2 polymorphism. Post-discharge, we followed up with 68 patients over 30 to 45 days, dividing them into depressive (29 patients) and non-depressive (39 patients) groups based on their Beck Depression Inventory scores.

RESULTS

We categorized 68 patients into three groups based on their genotypes: Thr/Thr (22 patients), Thr/Ala (41 patients), and Ala/Ala (5 patients). Depressive symptoms were less frequent in the Thr/Ala group (29.3%) compared to the Thr/Thr (59.1%) and Ala/Ala (60%) groups ( = 0.048). The Thr/Ala heterozygous genotype correlated with a lower risk of post-COVID-19 depression, as shown by univariate and multivariate logistic regression analyses. These analyses, adjusted for various factors, indicated a 70% to 81% reduction in risk.

CONCLUSION

Our findings appear to be the first to show that heterozygosity for Thr92Ala-DIO2 in patients with COVID-19 may protect against post-COVID-19 depression symptoms up to 2 months after the illness.

摘要

背景

Thr92Ala-DIO2 多态性与 COVID-19 住院患者和神经精神疾病的临床结局相关。本研究探讨了 Thr92Ala-DIO2 多态性对中度至重度 SARS-CoV-2 感染后出院患者神经心理症状（尤其是抑郁症状）的影响。

方法

我们的前瞻性队列研究于 2020 年 6 月至 8 月期间对 273 名 COVID-19 住院患者进行了数据收集。其中包括甲状腺功能检查、炎症标志物、血液学指标以及 Thr92Ala-DIO2 多态性的基因分型。出院后，我们对 68 名患者进行了 30 至 45 天的随访，根据贝克抑郁量表评分将他们分为抑郁组（29 名患者）和非抑郁组（39 名患者）。

结果

我们根据患者的基因型将 68 名患者分为三组：Thr/Thr（22 名患者）、Thr/Ala（41 名患者）和 Ala/Ala（5 名患者）。Thr/Ala 组（29.3%）的抑郁症状发生率低于 Thr/Thr 组（59.1%）和 Ala/Ala 组（60%）（ = 0.048）。单因素和多因素 logistic 回归分析显示，Thr/Ala 杂合基因型与 COVID-19 后发生抑郁的风险降低相关。这些分析调整了各种因素后，表明风险降低了 70%至 81%。

结论

我们的研究结果似乎是首次表明，COVID-19 患者 Thr92Ala-DIO2 的杂合性可能在疾病后 2 个月内保护其免受 COVID-19 后抑郁症状的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/d2f016408b5b/fendo-15-1366500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/d0764326ea8b/fendo-15-1366500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/40448aff613f/fendo-15-1366500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/d2f016408b5b/fendo-15-1366500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/d0764326ea8b/fendo-15-1366500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/40448aff613f/fendo-15-1366500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d420/11190161/d2f016408b5b/fendo-15-1366500-g003.jpg

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